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Treatment starts at 1.5 mg once daily for the first 30 days, increases to 4 mg for days 3160, then 9 mg for days 6190, before reaching the 25 mg maintenance dose on day 91
2021;78:e38e50
Here, we see that 5FU can induce changes in mitochondrial abundance in HCT116 cancer cells but fails to induce similar changes in hMSCs, evidenced by NAO staining and protein expression (Extended Data Fig
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Phase I dose-escalation clinical trial, revealed that PT2385 was well tolerated, with no dose-limiting toxicities
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